IL1 receptor antagonist protein (30R-1073)
Purified recombinant Human IL1 receptor antagonist protein
|Synonyms||Anakinra protein, Interleukin-1 receptor antagonist protein, , IL1 inhibitor protein, IL-1, IL 1, IL1F3 protein, IL-1 protein, IL-1ra protein, ICIL-1RA protein, IL 1 protein, IL1, IL1RN protein, ICIL 1RA protein, Interleukin-1 receptor antagonist protein protein, ICIL1RA protein, IRAP protein, IL-1RN protein, IL1 inhibitor protein, IL1RA protein|
Coomassie Blue stained SDS-PAGE of IL1 receptor antagonist protein (30R-1073)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE|
|Grade & Purity||> 95% pure|
|Molecular Weight||17.2 kDa (153aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in PBS, pH 7.4.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||One of the most potent pro-inflammatory mediators is the early-acting cytokine interleukin-1 (IL-1), whose actions are regulated by the structurally related IL-1 receptor antagonist (IL-1 RA). IL-1 RA is a competitive IL-1 inhibitor and a powerful anti-inflammatory agent. Also, Several autoimmune and inflammatory diseases have been associated with an allelic polymorphism of the IL-1 RA gene. Recombinant human IL-1 RA was expressed in E. coli and purified by using conventional chromatography techniques.|
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