IL13 Variant protein (30R-AI109)

Purified recombinant Human IL13 Variant protein

Synonyms IL 13, IL13, IL-13 Variant protein, IL 13 protein, IL-13 protein, Interleukin 13 Variant protein, protein, IL-13
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL13 protein corresponding to amino acids MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 12.5 kDa
Form & Buffer Lyophilized from 10 mM sodium citrate, pH 4.0.

Usage & Assay Information

Bioactivity This IL-13 analog shows a two fold increase, relative to wild type IL-13, in bioactivity as measured by the in-vitro dose dependent activation of STAT6 and IL-13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhi

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL13 in mice resulted in impaired Th2 cell development and indicated an important role for IL13 in the expulsion of gastrointestinal parasites. IL13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL1beta, TNF-alpha, IL6 and IL8. IL13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL13 activity inhibits the pathophysiology of asthma.

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Availability: In stock

Price: £180.28
Size: 10 ug
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