IL2R alpha protein (30R-AS048)

Purified recombinant Human IL2R alpha protein

Synonyms CD25 antigen protein, IL-2R alpha protein, TAC-antigen protein, Interleukin 2R alpha protein, IL 2, IL 2 protein, IL2, IL-2, soluble IL-2 receptor protein, IL-2 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL2 protein corresponding to amino acids ELCDDDPPEI PHATFKAMAY KEGTMLNCEC KRGFRRIKSG SLYMLCTGNS SHSSWDNQCQ CTSSATRNTT KQVTPQPEEQ KERKTTEMQS PMQPVDQASL PGHCREPPPW ENEATERIYH FVVGQMVYYQ CVQGYRALHR GPAESVCKMT HGKTRWTQPQ LICTGEMETS QFPGEEKPQA SPEGRPESET SCLVTTTDFQ IQTEMAATME TSIFTTEYQ.
Expression System Hi-5 cells
Grade & Purity > 98% pure
Molecular Weight 31 kDa
Form & Buffer Lyophilized from PBS. Reconstitute with PBS, pH 7.2 to a concentration of 0.1 - 1.0 mg/ml.

Usage & Assay Information

Bioactivity Determined by its ability to increase the proliferation effect of IL-2 in Mouse CTLL-2 cells. In the presence of 1 ng/ml of recombinant IL-2, the expected ED50 for this effect is between 0.5 - 1.5 ug/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance The IL2 receptor system consists of three non-covalently linked subunits termed IL2Ra, IL2Rbeta, and IL2R?. The IL2Ra is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL2 signals. Proteolytic processing of IL2Ra releases the entire extracellular domain of IL2Ra thereby generating a 219 amino acid soluble protein called soluble IL2Ra (sIL2Ra). The homodimeric form binds IL2 (kDa=10nM) and facilitates IL2 signaling.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: £180.28
Size: 25 ug
OR
Shipping
View Our Distributors