IL33 protein (30R-1105)
Purified recombinant Human IL33 protein
|Synonyms||IL-33 protein, Interleukin33 protein, DVS27 related protein protein, RP11 575C20.2 protein, Interleukin 33 CHROMOSOME 9 OPEN READING FRAME 26 protein, C9orf26 protein, DKFZp586H0523 protein, Interleukin 33 protein, IL33, IL-33, NFHEV protein, INTERLEUKIN 33 NFHEV protein, Interleukin 1 family member 11 protein, NKHEV protein, IL 1F11 protein, DVS27 protein, NF HEV protein, il33, IL 33 protein, IL 33 protein, Interleukin 33 precursor protein, IL1F11 protein, IL-33 protein, Nuclear factor from high endothelial venules protein, IL 33, NF-HEV protein|
Coomassie Blue stained SDS-PAGE of IL33 protein (30R-1105)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||112-270 amino acids: MSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET|
|Grade & Purity||> 95% pure|
|Molecular Weight||18.1Da (160aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1. Recombinant human IL-33(C-terminal fragment) was expressed in E. coli and purified by using conventional chromatography techniques.|
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