IL4R alpha protein (30R-AS049)

Purified recombinant Human IL4R alpha protein

Synonyms IL 4, soluble IL-4 receptor alpha protein, IL4, CD124 protein, IL-4, IL-4 protein, Interleukin 4R alpha protein, IL-4Ralpha protein, IL 4 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of IL4R protein corresponding to amino acids GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH.
Expression System 293 cells
Grade & Purity > 98% pure
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity The ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is approximately 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4), corresponding to a specific activity of approximately 2 x 10^5 units/mg.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance IL4 can signal through type I and type II receptor complexes, which share a common gamma chain (?c). The type I receptor contains in addition to the ? chain an IL4Ra subunit, whereas the type II receptor contains the IL13Ra. The secreted extracellular domain of IL4Ra, called sIL4Ra, binds IL4 and antagonizes its activity. It plays an important role in regulating the differentiation of naive CD4+ T cells and class switching to IgG1 and IgE.

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Availability: In stock

Price: £180.28
Size: 15 ug
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