INPP5D antibody (70R-10226)

Affinity purified rabbit polyclonal INPP5D antibody

Synonyms Polyclonal INPP5D antibody, Anti-INPP5D antibody, MGC142142 antibody, hp51CN antibody, INPP5D, INPPD-5, SHIP antibody, SIP-145 antibody, inositol polyphosphate-5-phosphatase, INPPD 5 antibody, MGC142140 antibody, MGC104855 antibody, INPPD-5 antibody, 145kDa antibody, INPPD 5, SHIP1 antibody
Cross Reactivity Human
Applications WB
Immunogen INPP5D antibody was raised in rabbit using the C terminal of INPP5D as the immunogen
Assay Information INPP5D Blocking Peptide, catalog no. 33R-7282, is also available for use as a blocking control in assays to test for specificity of this INPP5D antibody

Images

Western Blot analysis using INPP5D antibody (70R-10226)

Western Blot showing INPP5D antibody used at a concentration of 1 ug/ml against THP-1 Cell Lysate

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.

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Images

  • Western Blot analysis using INPP5D antibody (70R-10226) | Western Blot showing INPP5D antibody used at a concentration of 1 ug/ml against THP-1 Cell Lysate

Availability: In stock

Price: £276.43
Size: 50 ug
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