IPP1 protein (His tag) (80R-1040)
Purified recombinant Human IPP1 protein
|Synonyms||I1 protein, Protein phosphatase inhibitor protein, Inhibitor 1 protein, IPP-1 protein, IPP 1 protein, I 1 protein, IPP 1 protein, Protein phosphatase 1 regulatory subunit 1A., IPP-1, IPP 1, PPP1R1A protein, Protein phosphatase 1 regulatory (inhibitor) subunit 1A protein, Protein phosphatase inhibitor-1 Protein phosphatase inhibitor 1 protein, IPP1 protein, IPP1|
Coomassie Blue stained SDS-PAGE of IPP1 protein (His tag) (80R-1040)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-171 amino acids: MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS VLEHHHHHH|
|Grade & Purity||> 90% pure|
|Molecular Weight||20 kDa (179aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 50mM Tris, pH 8.0, containing 0.1mM PMSF, 1mM EDTA, 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Protein phosphatase inhibitor-1 (IPP-1) plays an important role in the regulation of glycogen metabolism through inhibition of type-1 protein serine/threonine phosphatase (PP1) activity, and it has been implicated in the regulation of cell growth. IPP-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. In the presence of calcium, PPI-1 is inactivated by calcineurin (or PP2B). Recombinant human IPP-1, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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