KCNIP3 protein (His tag) (80R-1550)
Purified recombinant Human KCNIP3 protein
|Synonyms||KCNIP 3 protein, Calsenilin protein, MGC18289, KCHIP3 protein, CSEN protein, KCNIP 3, KCNIP-3 protein, KCNIP3, KCNIP-3, DREAM protein|
Coomassie Blue stained SDS-PAGE of KCNIP3 protein (His tag) (80R-1550)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-256 amino acids: MGSSHHHHHH SSGLVPRGSH MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG YITKEEMLAI MKSIYDMMGR HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ KDENIMSSMQ LFENVI|
|Grade & Purity||> 90% pure|
|Molecular Weight||31.4 kDa (276aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 2mM DTT and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||KCNIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins containing EF-hand-like domains. This protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Recombinant human KCNIP3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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