Latexin protein (30R-1277)
Purified recombinant Human Latexin protein
|Synonyms||Endogenous carboxypeptidase inhibitor protein, ECI protein, TCI protein, Latexin protein, Latexin protein protein, Tissue carboxypeptidase inhibitor., LXN protein, MUM protein|
Coomassie Blue stained SDS-PAGE of Latexin protein (30R-1277)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-222 amino acids: MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH KYRLKFAVEE IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD EEDNTFYQRL KSMKEPLEAQ NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY TILLHNIASQ EIIPWQMQVL WHPQYGTKVK HNSRLPKEVQ LE|
|Grade & Purity||> 95% pure|
|Molecular Weight||25.7 kDa (222aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 50mM NaCl, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Latexin, a carboxypeptidase A inhibitor, is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low expression occurs in other tissues including brain. Latexin has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1. It is down-regulated in the presenilin-1-deficient mouse brain, thus putatively playing a role in Alzheimer's disease. Recombinant human Latexin protein was expressed in E. coli and purified by using conventional chromatography.|
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