Lin28 protein (His tag) (80R-1211)
Purified recombinant Human Lin28 protein
|Synonyms||Lin 28, Lin 28 homolog protein, ZCCHC1 protein, CSDD1 protein, Zinc finger CCHC domain-containing protein 1 AL024421.Lin 28 protein, Lin-28, Lin28, Lin-28 protein, FLJ12457 protein, Lin28a protein, LIN-28 protein, LIN28A protein, RNA binding protein lin 28 protein, Zinc finger CCHC domain containing protein 1., Lin 28 protein, elegans) protein, Tex17 protein, Lin 28 homolog A protein, Lin 28 homolog (C protein|
Coomassie Blue stained SDS-PAGE of Lin28 protein (His tag) (80R-1211)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||42-209 amino acids: MGSSHHHHHH SSGLVPRGSH RSMGICKWFN VRMGFGFLSM TARAGVALDP PVDVFVHQSK LHMEGFRSLK EGEAVEFTFK KSAKGLESIR VTGPGGVFCI GSERRPKGKS MQKRRSKGDR CYNCGGLDHH AKECKLPPQP KKCHFCQSIS HMVASCPLKA QQGPSAQGKP TYFREEEEEI HSPTLLPEAQ N|
|Grade & Purity||> 90% pure|
|Molecular Weight||21.1 kDa (191aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Lin-28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. It is marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. It has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells. Recombinant Lin28 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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