MAP2K3 protein (His tag) (80R-1757)
Purified recombinant Human MAP2K3 protein
|Synonyms||MAP2K3, MKK3 protein, MAPK3-2, MAPK3-2 protein, PRKMK3 protein, MAPK3 2, MAPK3 2 protein, MAPKK3 protein, Dual specificity mitogen-activated protein kinase kinase 3 protein, MEK3 protein|
Coomassie Blue stained SDS-PAGE of MAP2K3 protein (His tag) (80R-1757)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-318 amino acids: MGSSHHHHHH SSGLVPRGSH MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK TKKTDIAAFV KEILGEDS|
|Grade & Purity||> 90% pure|
|Molecular Weight||38.3 kDa (338aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||MAP2K3, also known as dual specificity mitogen-activated protein kinase kinase 3, is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Recombinant human MAP2K3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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