MAPKAPK3 antibody (70R-10035)
Affinity purified rabbit polyclonal MAPKAPK3 antibody
|Synonyms||Polyclonal MAPKAPK3 antibody, Anti-MAPKAPK3 antibody, MAPKAPK3, 3PK antibody, MAPKAPK-3 antibody, MAPKAP3 antibody, MAPKAPK 3 antibody, mitogen-activated protein kinase-activated protein kinase 3 antibody, MAPKAPK-3, MAPKAPK 3|
|Immunogen||MAPKAPK3 antibody was raised in rabbit using the C terminal of MAPKAPK3 as the immunogen|
|Assay Information||MAPKAPK3 Blocking Peptide, catalog no. 33R-4327, is also available for use as a blocking control in assays to test for specificity of this MAPKAPK3 antibody|
Western Blot analysis using MAPKAPK3 antibody (70R-10035)
MAPKAPK3 antibody (70R-10035) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||MAPKAPK3 is a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.|
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