MAPRE1 protein (His tag) (80R-1610)
Purified recombinant Human MAPRE1 protein
|Synonyms||MAPRE-1 protein, MAPRE 1 protein, MAPRE-1, MAPRE 1, MAPRE1, Microtubule-associated protein RP/EB family member 1. protein, EB1 protein, MGC129946, MGC117374 protein|
Coomassie Blue stained SDS-PAGE of MAPRE1 protein (His tag) (80R-1610)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-268 amino acids: MGSSHHHHHH SSGLVPRGSH MAVNVYSTSV TSDNLSRHDM LAWINESLQL NLTKIEQLCS GAAYCQFMDM LFPGSIALKK VKFQAKLEHE YIQNFKILQA GFKRMGVDKI IPVDKLVKGK FQDNFEFVQW FKKFFDANYD GKDYDPVAAR QGQETAVAPS LVAPALNKPK KPLTSSSAAP QRPISTQRTA AAPKAGPGVV RKNPGVGNGD DEAAELMQQV NVLKLTVEDL EKERDFYFGK LRNIELICQE NEGENDPVLQ RIVDILYATD EGFVIPDEGG PQEEQEEY|
|Grade & Purity||> 90% pure|
|Molecular Weight||32.2 kDa (288aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 2mM DTT and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||MAPRE1, also known as EB1, belongs to the intermediate/early gene family. This protein was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. It localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. MAPRE1 is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Recombinant human MAPRE1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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