MCFD2 protein (T7 tag) (80R-1240)
Purified recombinant Human MCFD2 protein (T7 tag)
|Synonyms||LMAN1IP protein, F5F8D protein, Neural stem cell derived neuronal survival protein protein, MCFD2, MCFD-2, DKFZp686G21263 protein, Multiple coagulation factor deficiency protein 2., SDNSF protein, MCFD 2 protein, MCFD 2, MCFD-2 protein, Multiple coagulation factor deficiency 2 MCFD 2 protein|
Coomassie Blue stained SDS-PAGE of MCFD2 protein (T7 tag) (80R-1240)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||27-146 amino acids: MASMTGGQQM GRGSHMEEPA ASFSQPGSMG LDKNTVHDQE HIMEHLEGVI NKPEAEMSPQ ELQLHYFKMH DYDGNNLLDG LELSTAITHV HKEEGSEQAP LMSEDELINI IDGVLRDDDK NNDGYIDYAE FAKSLQ|
|Grade & Purity||> 90% pure|
|Molecular Weight||15.1 kDa (136aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 100mM NaCl and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Multiple coagulation factor deficiency 2 (MCFD2), also known as SDNSF. This is expressed by neural stem/progenitor cells of the hippocampus, and localized to regions where neurogenesis persists throughout life. It has been found to prevent NSC cell death and to maintain stem cell characteristics. This protein forms a complex with LAMN1 that facilitates the transport of coagulation factors V and VIII from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment. Mutations in the MCFD2 gene may cause Factor V and Factor VIII combined deficiency. Recombinant human MCFD2, fused to T7-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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