MCM10 antibody (70R-5512)

Rabbit polyclonal MCM10 antibody raised against the middle region of MCM10

Synonyms Polyclonal MCM10 antibody, Anti-MCM10 antibody, CNA43 antibody, MCM-10 antibody, MCM 10 antibody, MGC126776 antibody, MCM-10, MCM 10, Minichromosome Maintenance Complex Component 10 antibody, PRO2249 antibody, MCM10
Specificity MCM10 antibody was raised against the middle region of MCM10
Cross Reactivity Human
Applications WB
Immunogen MCM10 antibody was raised using the middle region of MCM10 corresponding to a region with amino acids PKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERV
Assay Information MCM10 Blocking Peptide, catalog no. 33R-7173, is also available for use as a blocking control in assays to test for specificity of this MCM10 antibody

Images

Western Blot analysis using MCM10 antibody (70R-5512)

MCM10 antibody (70R-5512) used at 1 ug/ml to detect target protein.

Specifications

Host Rabbit
Method of Purification Affinity purified
Molecular Weight 98 kDa (MW of target protein)
Form & Buffer Lyophilized powder. Add 50ul distilled water for a 1mg/ml concentration of MCM10 antibody in PBS
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding.

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Images

  • Western Blot analysis using MCM10 antibody (70R-5512) | MCM10 antibody (70R-5512) used at 1 ug/ml to detect target protein.

Availability: In stock

Price: £250.71
Size: 50 ug
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