MESDC2 protein (His tag) (80R-1691)
Purified recombinant Human MESDC2 protein
|Synonyms||MESDC-2 protein, MESDC2, LDLR chaperone MESD protein, MESDC 2 protein, MESD, MESDC-2, KIAA0081 protein, BOCA protein, MESDC 2|
Coomassie Blue stained SDS-PAGE of MESDC2 protein (His tag) (80R-1691)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||34-234 amino acids: MGSSHHHHHH SSGLVPRGSH MAEGSPGTPD ESTPPPRKKK KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPVD FSKIDPSKPE SILKMTKKGK TLMMFVTVSG SPTEKETEEI TSLWQGSLFN ANYDVQRFIV GSDRAIFMLR DGSYAWEIKD FLVGQDRCAD VTLEGQVYPG KGGGSKEKNK TKQDKGKKKK EGDLKSRSSK EENRAGNKRE DL|
|Grade & Purity||> 90% pure|
|Molecular Weight||24.9 kDa (222aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||MESDC2, also known as Mesoderm development candidate 2, is required for formation of the primitive streak and mesoderm during embryogenesis. This protein binds to the Wnt co-receptors LRP5 and LRP6 in the endoplasmic reticulum and is required for their proper folding and cell surface expression. Recombinant human MESDC2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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