Midkine protein (30R-AM012)

Purified recombinant Human Midkine protein

Synonyms MK protein, NEGF-2 protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of Midkine protein corresponding to amino acids VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 13.4 kDa
Form & Buffer Lyophilized from PBS, pH 7.4. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

Usage & Assay Information

Bioactivity Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Midkine (MK) and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis.

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Availability: In stock

Price: £180.28
Size: 20 ug
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