MIP1 alpha protein (Mouse) (30R-AM050)

Purified recombinant Mouse MIP1 alpha protein

Synonyms CCL3 protein, MIP-1 alpha protein, MIP-1 alpha protein, MIP 1 alpha protein, MIP1 alpha, Macrophage Inflammatory Protein-1 alpha protein, LD78 alpha protein, MIP-1 alpha, MIP 1 alpha
Species Mouse
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of MIP1 alpha protein corresponding to amino acids APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 7.8 kDa
Form & Buffer Supplied as a lyophilized powder.

Usage & Assay Information

Bioactivity Determined by its ability to chemoattract Mouse balb/c splenocytes using a concentration range of 10.0-100.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and Mouse MIP-1 alpha and MIP-1 beta are active on human and Mouse hematopoietic cells.

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Availability: In stock

Price: £180.28
Size: 10 ug
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