MIP1 beta antibody (70-MR34)

Affinity purified Rabbit polyclonal MIP1 beta antibody

Synonyms Polyclonal MIP1 beta antibody, Anti-MIP1 beta antibody, MIP beta-1 antibody, MIP beta 1, MIP beta-1, MIP beta 1 antibody, Macrophage Inflammatory antibody-1beta antibody, MIP1 beta, ACT-2 antibody, CCL4 antibody, MIP-1 beta antibody
Specificity Human MIP1 beta
Cross Reactivity To be determined by end-user
Applications ELISA, Inhibition, WB
Immunogen MIP1 beta antibody was raised in rabbit using highly pure recombinant human MIP1 betaas the immunogen.

Specifications

Host Rabbit
Molecular Weight 7.8 kDa (predicted detection band MW)
Form & Buffer Lyophilized from PBS, pH 7.2. Reconstitute in sterile water at a concentration of >0.2 mg/ml.

Usage & Assay Information

Usage Recommendations ELISA: 0.5-2 ug/ml, Inhibition: 1.75-3 ug/ml, WB: 0.1-0.2 ug/ml

Storage & Safety

Storage Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and Mouse MIP-1 alpha and MIP-1 beta are active on human and Mouse hematopoietic cells.

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Availability: In stock

Price: £192.30
Size: 50 ug
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