MRGPRX2 antibody (70R-9930)
Affinity purified rabbit polyclonal MRGPRX2 antibody
|Synonyms||Polyclonal MRGPRX2 antibody, Anti-MRGPRX2 antibody, MRGPRX2, member X2 antibody, MRGPRX-2 antibody, MRGX2 antibody, MRGPRX-2, MAS-related GPR, MRGPRX 2, MRGPRX 2 antibody|
|Immunogen||MRGPRX2 antibody was raised in rabbit using the middle region of MRGPRX2 as the immunogen|
|Assay Information||MRGPRX2 Blocking Peptide, catalog no. 33R-9456, is also available for use as a blocking control in assays to test for specificity of this MRGPRX2 antibody|
Western Blot analysis using MRGPRX2 antibody (70R-9930)
MRGPRX2 antibody (70R-9930) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||MRGPRX2 is an orphan receptor. It probably involved in the function of nociceptive neurons. It also may regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca2+ but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.|
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