Noggin protein (30R-AN039)

Purified recombinant Human Noggin protein

Synonyms SYM 1 protein, SYNS 1 protein, SYM1 protein, SYNS1 protein, Synostoses (multiple) syndrome 1 protein, NOG protein, Symphalangism 1 (proximal) protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Expression System E.coli
Grade & Purity > 95% pure
Molecular Weight 46 kDa
Form & Buffer Supplied as a lyophilized powder.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF beta family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2, -7, -13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system.

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Availability: In stock

Price: £180.28
Size: 20 ug
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