NXT1 protein (His tag) (80R-1802)
Purified recombinant Human NXT1 protein
|Synonyms||NXT 1, MTR2 protein, NTF2-related export protein 1 protein, P15 protein, NXT1, NXT-1, NXT 1 protein, NXT-1 protein|
Coomassie Blue stained SDS-PAGE of NXT1 protein (His tag) (80R-1802)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-140 amino acids: MGSSHHHHHH SSGLVPRGSH MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN AVSGQESLSE FFEMLPSSEF QISVVDCQPV HDEATPSQTT VLVVICGSVK FEGNKQRDFN QNFILTAQAS PSNTVWKIAS DCFRFQDWAS|
|Grade & Purity||> 85% pure|
|Molecular Weight||18.0 kDa (160aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||NXT1 functions as a nuclear export factor in both RAN (Ras-related nuclear protein) and CRM1 (required for chromosome region maintenance) dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. This protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. Recombinant human NXT1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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