OAS1 protein (His tag) (80R-1190)
Purified recombinant Human OAS1 protein
|Synonyms||2 5A synthetase 1 protein, OAS 1, p46/p42 OAS protein, , 2'5' oligoadenylate synthetase 1 protein, 5?-oligoadenylate synthetase 1 protein, IFI 4 protein, IFI4 protein, isoform2 (2 5')oligo(A) synthetase 1 protein, 2'5' oligo A synthetase 1 protein, IFI-4 protein, OAS-1 protein, 2' 5' oligoisoadenylate synthetase 1 protein, OAS-1, 2' 5' oligo A synthetase 1 protein, OAS1, 2' 5' oligoadenylate synthetase 1 protein, OIAS protein, 2'5' oligoisoadenylate synthetase 1 protein, 2 5 Oligoadenylate Synthetase 1 protein, E18/E16 protein, OAS 1 protein, OAS 1 protein, 2? protein, OIASI protein|
Coomassie Blue stained SDS-PAGE of OAS1 protein (His tag) (80R-1190)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-364 amino acids: MGSSHHHHHH SSGLVPRGSH MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS YPVCVSKVVK GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ EIRRQLEACQ RERAFSVKFE VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL PAFDALGQLT GSYKPNPQIY VKLIEECTDL QKEGEFSTCF TELQRDFLKQ RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW ERGSMKTHFN TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLVRPP ASSLPFIPAP LHEA|
|Grade & Purity||> 95% pure|
|Molecular Weight||43.9 kDa (384aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||OAS1 is an enzyme included in the 2?,5?-oligoadenylate synthase family. This enzyme is induced by interferons and uses adenosine triphosphate in 2?-specific nucleotidyl transfer reactions to synthesize 2?,5?-oligoadenylates(2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. OAS1 may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. Recombinant OAS1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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