OAT protein (30R-1458)
Purified recombinant Human OAT protein
|Synonyms||OATASE protein, HOGA protein, Ornithine aminotransferase protein, Ornithine--oxo-acid aminotransferase., mitochondrial precursor protein, DKFZp781A11155 protein, ornithine aminotransferase precursor protein, ornithine aminotransferase (gyrate atrophy) protein, ornithine aminotransferase precursor EC 188.8.131.52 protein, Ornithine oxo-acid aminotransferase protein|
Coomassie Blue stained SDS-PAGE of OAT protein (30R-1458)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||33-439 amino acids: MTVQGPPTSD DIFEREYKYG AHNYHPLPVA LERGKGIYLW DVEGRKYFDF LSSYSAVNQG HCHPKIVNAL KSQVDKLTLT SRAFYNNVLG EYEEYITKLF NYHKVLPMNT GVEAGETACK LARKWGYTVK GIQKYKAKIV FAAGNFWGRT LSAISSSTDP TSYDGFGPFM PGFDIIPYND LPALERALQD PNVAAFMVEP IQGEAGVVVP DPGYLMGVRE LCTRHQVLFI ADEIQTGLAR TGRWLAVDYE NVRPDIVLLG KALSGGLYPV SAVLCDDDIM LTIKPGEHGS TYGGNPLGCR VAIAALEVLE EENLAENADK LGIILRNELM KLPSDVVTAV RGKGLLNAIV IKETKDWDAW KVCLRLRDNG LLAKPTHGDI IRFAPPLVIK EDELRESIEI INKTILSF|
|Grade & Purity||> 90% pure|
|Molecular Weight||45.2 kDa (408aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||OAT, also known as mitochondrial enzyme ornithine aminotransferase, is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Recombinant OAT protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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