PAI1 antibody (70R-PR018)

Affinity purified Rabbit polyclonal PAI1 antibody

Synonyms Polyclonal PAI1 antibody, Anti-PAI1 antibody, PAI-1, PAI 1 antibody, Plasminogen Activator Inhibitor-1 antibody, Serpin E1 antibody, PAI1, PAI-1 antibody, PAI 1, PAI-1 antibody
Specificity Human PAL1
Cross Reactivity To be determined by end-user
Applications ELISA, Inhibition, WB
Immunogen PAI1 antibody was raised in rabbit using highly pure recombinant human PAI-1 as the immunogen.

Specifications

Host Rabbit
Molecular Weight 42.7 kDa (predicted detection band MW)
Form & Buffer Lyophilized from PBS, pH 7.2.

Usage & Assay Information

Usage Recommendations ELISA: 0.5-2 ug/ml, Inhibition: >15 ug/ml, WB: 0.1-0.2 ug/ml

Storage & Safety

Storage Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Plasminogen Activator Inhibitor-1 (PAI-1, Serpin E1) is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA). PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFa, glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases.

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Availability: In stock

Price: £180.28
Size: 50 ug
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