PDCD6 protein (His tag) (80R-1736)
Purified recombinant Human PDCD6 protein
|Synonyms||Apoptosis-linked gene 2 protein, Programmed cell death protein 6 protein, PDCD 6, FLJ46208 protein, PDCD-6, PDCD6, PEF1B protein, PDCD-6 protein, PDCD 6 protein, programmed cell death 6 protein, MGC111017 protein, ALG-2 protein, apoptosis-linked gene-2 protein|
Coomassie Blue stained SDS-PAGE of PDCD6 protein (His tag) (80R-1736)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-191 amino acids: MGSSHHHHHH SSGLVPRGSH MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V|
|Grade & Purity||> 95% pure|
|Molecular Weight||24.0 kDa (211aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 10mM sodium citrate, pH 3.5, containing 40% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Programmed cell death 6, also known as PDCD6, is calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Recombinant human PDCD6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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