PDK1 protein (His tag) (80R-1103)
Purified recombinant Human PDK1 protein
|Synonyms||Mitochondrial pyruvate dehydrogenase kinase isoenzyme1 protein, isoenzyme 1., Pyruvate dehydrogenase kinase protein, PDK1, PDK 1 protein, Pyruvate dehydrogenase kinase protein, isozyme 1 protein, PDK-1 protein, isozyme 1 HGNC:8809 protein, PDK 1, Pyruvate dehydrogenase kinase protein, PDK1 protein, PDK-1, Pyruvate dehydrogenase kinase isoform 1 protein|
Coomassie Blue stained SDS-PAGE of PDK1 protein (His tag) (80R-1103)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||29-436 amino acids: MGSSHHHHHH SSGLVPRGSH MSSDSGSSPA SERGVPGQVD FYARFSPSPL SMKQFLDFGS VNACEKTSFM FLRQELPVRL ANIMKEISLL PDNLLRTPSV QLVQSWYIQS LQELLDFKDK SAEDAKAIYD FTDTVIRIRN RHNDVIPTMA QGVIEYKESF GVDPVTSQNV QYFLDRFYMS RISIRMLLNQ HSLLFGGKGK GSPSHRKHIG SINPNCNVLE VIKDGYENAR RLCDLYYINS PELELEELNA KSPGQPIQVV YVPSHLYHMV FELFKNAMRA TMEHHANRGV YPPIQVHVTL GNEDLTVKMS DRGGGVPLRK IDRLFNYMYS TAPRPRVETS RAVPLAGFGY GLPISRLYAQ YFQGDLKLYS LEGYGTDAVI YIKALSTDSI ERLPVYNKAA WKHYNTNHEA DDWCVPSREP KDMTTFRSA|
|Grade & Purity||> 95% pure|
|Molecular Weight||48.6 kDa (429 aa)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.0, containing 100mM NaCl, 0.5mM DTT, 0.1mM EDTA, 0.1mM PMSF, 1mM MgCl2, and 40% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PDK1 (pyruvate dehydrogenase kinase isoform 1) is involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase (PDH) that is a part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 has been found to serve as an effective therapeutic target for inhibition of glioblastoma growth. Recombinant human PDK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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