PEA15 protein (30R-1399)
Purified recombinant Human PEA15 protein
|Synonyms||PEA 15 protein, MAT 1 protein, PEA-15, HUMMAT1H protein, PEA 15 protein, PEA15 protein, Phosphoprotein enriched in astrocytes 15 protein, Phosphoprotein enriched in astrocytes protein, PEA15, MAT 1H protein, PEA-15 protein, PEA 15, Phosphoprotein enriched in diabetes., Astrocytic phosphoprotein PEA-15 protein, 15kD Astrocytic phosphoprotein PEA 15 protein, PED protein, HMAT 1 protein, Homolog of mouse MAT1 oncogene protein, Homolog of mouse MAT 1 oncogene protein, MAT1 protein, HMAT1 protein, Astrocytic phosphoprotein PEA15 protein, Phosphoprotein enriched in astrocytes 15kD protein, MAT1H protein, HUMMAT 1H protein, PEA15 protein protein|
Coomassie Blue stained SDS-PAGE of PEA15 protein (30R-1399)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-130 amino acids: MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA|
|Grade & Purity||> 90% pure|
|Molecular Weight||15 kDa (130aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 1mM DTT and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Phospho-enriched protein in astrocytes 15 kDa (PEA-15) is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes. This protein has been implicated in the regulation of multiple cellular processes including apoptosis, proliferation, glucose transport, adhesion and migration. Increased PEA-15 levels may affect tumorigenesis and cancer progression, thus it is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. Recombinant human PEA-15 was expressed in E. coli and purified by using conventional chromatography.|
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