PFN2 protein (His tag) (80R-1300)
Purified recombinant Human PFN2 protein
|Synonyms||PFN-2, PFN-2 protein, Profilin2, Profilin II protein, ProfilinII protein, PFN2 protein, PFN 2, PFL protein, PFN 2 protein, PFN 2 protein, PFN2, Profilin 2 D3S1319E protein|
Coomassie Blue stained SDS-PAGE of PFN2 protein (His tag) (80R-1300)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-140 amino acids: MGSSHHHHHH SSGLVPRGSH MAGWQSYVDN LMCDGCCQEA AIVGYCDAKY VWAATAGGVF QSITPIEIDM IVGKDREGFF TNGLALGAKK CSVIRDSLYV DGDCTMDIRT KSQGGEPTYN VAVGRAGRVL VFVMGKEGVH GGGLNKKAYS MAKYLRDSGF|
|Grade & Purity||> 95% pure|
|Molecular Weight||17.2 kDa (160aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PFN2 is a ubiquitous actin monomer-binding protein belonging to the profilin family. This protein is ubiquitously expressed with highest expression in kidney, brain and skeletal muscle. Like other members of the profilin family, PFN2 functions as an actin monomer-binding protein that influences the structure of the cytoskeleton by regulating actin polymerization in response to extracellular signals. At high concentrations, it prevents the polymerization of actin whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Recombinant PFN2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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