PGP9.5 protein (30R-1093)
Purified recombinant Human PGP9.5 protein
|Synonyms||Ubiquitin carboxyl-terminal esterase L1 Gracile axonal dystrophy protein, Ubiquitin thiolesterase protein, PGP9.5 protein, Protein gene product 9.5 protein, Neuron cytoplasmic protein 9.5 protein, Ubiquitin C terminal esterase L1 protein, Neuron cytoplasmic protein 9.5 protein, Ubiquitin carboxyl-terminal hydrolase isozyme L1 protein, PGP 9.5 protein, EC 22.214.171.124 protein, Ubiquitin thiolesterase L1., Park 5 protein, Ubiquitin thioesterase L1 protein, PGP9.5 protein, 1-223aa protein, UCH-L1 protein, Parkinson Disease 5 protein, Ubiquitin carboxyl terminal esterase L1 protein, Ubiquitin carboxyl terminal hydrolase isozyme L1 protein, UCH L1 protein, PGP95 protein, Ubiquitin C terminal hydrolase (neuron specific) protein, UCHL1 protein|
Coomassie Blue stained SDS-PAGE of PGP9.5 protein (30R-1093)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-223 amino acids: MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA|
|Grade & Purity||> 95% pure|
|Molecular Weight||24.8 kDa (223 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl, pH 8.0, containing 2mM EDTA.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PGP9.5/UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. PGP9.5 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Recombinant PGP9.5 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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