Pin1 antibody (10R-1035)

Mouse monoclonal Pin1 antibody

Synonyms Monoclonal Pin1 antibody, Anti-Pin1 antibody, PPIase antibody, Pin1, Rotamase Pin1 antibody, Pin 1, Pin 1 antibody, PIN1 antibody, PPIase Pin1 antibody, EC 5.2.1.8 antibody, PIN1 antibody, Pin-1 antibody, PPIase Pin1 antibody, EC 5.2.1.8 antibody, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, Pin-1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, Rotamase Pin1 antibody, UBL5 antibody, DOD antibody
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, WB
Immunogen Pin1 antibody was raised in mouse using recombinant human Pin1 (1-163aa) purified from E. coli as the immunogen.

Specifications

Host Mouse
Clone 3G8
Isotype IgG1 kappa
Source Anti-human Pin1 antibody, clone 3G8, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Pin1 protein.
Method of Purification Pin1 antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:500-1:1,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLk I, Wee, and Myt1 kinases), several transcription factors likebeta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.

References
Add a Paper

Sorry, but there are no references currently for this product.

Reviews

You need to be logged in to write a review. Please login here

Sorry there are currently no reviews for this product

Availability: In stock

Price: £212.33
Size: 100 ul
OR
Shipping
View Our Distributors