PINX1 protein (His tag) (80R-1144)
Purified recombinant Human PINX1 protein
|Synonyms||PINX1 protein, PINX-1, PINX 1 protein, TRF1-interacting protein 1 protein, PINX1, , Hepatocellular carcinoma-related putative tumor suppressor protein, PIN2-interacting protein 1 67-11-3 protein PIN2 interacting protein 1 protein, Protein 67-11-3 protein, PINX-1 protein, LPTS protein, Liver-related putative tumor suppressor protein, PIN2-interacting protein 1 protein, LPTL protein, PINX 1|
Coomassie Blue stained SDS-PAGE of PINX1 protein (His tag) (80R-1144)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-328 amino acids: MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK|
|Grade & Purity||> 95% pure|
|Molecular Weight||39.1 kDa (348aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||PINX1 (PIN2-interacting protein 1) is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. This protein contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. Recombinant human PINX1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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