PPP1R12A antibody (70R-10251)

Affinity purified rabbit polyclonal PPP1R12A antibody

Synonyms Polyclonal PPP1R12A antibody, Anti-PPP1R12A antibody, PPPR2A-1, PPP1R12A, MBS antibody, PPPR2A 1 antibody, regulatory, MYPT1 antibody, PPPR2A 1, MGC133042 antibody, protein phosphatase 1, PPPR2A-1 antibody, inhibitor subunit 12A antibody
Cross Reactivity Human
Applications WB
Immunogen PPP1R12A antibody was raised in rabbit using the C terminal of PPP1R12A as the immunogen
Assay Information PPP1R12A Blocking Peptide, catalog no. 33R-7509, is also available for use as a blocking control in assays to test for specificity of this PPP1R12A antibody

Images

Western Blot analysis using PPP1R12A antibody (70R-10251)

Western Blot showing PPP1R12A antibody used at a concentration of 1 ug/ml against Jurkat Cell Lysate

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.

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Images

  • Western Blot analysis using PPP1R12A antibody (70R-10251) | Western Blot showing PPP1R12A antibody used at a concentration of 1 ug/ml against Jurkat Cell Lysate

Availability: In stock

Price: £276.43
Size: 50 ug
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