PPP1R14A protein (His tag) (80R-1060)
Purified recombinant Human PPP1R14A protein
|Synonyms||CPI 17 alpha protein, PKC potentiated inhibitory protein of PP1 protein, PPP1INL protein, Protein phosphatase 1 protein, PPPR4A 1, Regulatory subunit 14A protein, regulatory (inhibitor) subunit 14A protein, CPI17 protein, PPPR4A 1 protein, PPPR4A -1 protein, Protein phosphatase 1 regulatory (inhibitor) subunit 14A protein, CPI-17 protein, PPP1R14A, PPPR4A -1, PPP1R14A protein, Protein phosphatase 1 regulatory subunit 14A protein, CPI 17alpha protein, regulatory (inhibitor) subunit 14A CPI 17 protein, Protein phosphatase 1 protein, CPI17 protein,|
Coomassie Blue stained SDS-PAGE of PPP1R14A protein (His tag) (80R-1060)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-147 amino acids: MGSSHHHHHH SSGLVPRGSH MAAQRLGKRV LSKLQSPSRA RGPGGSPGGL QKRHARVTVK YDRRELQRRL DVEKWIDGRL EELYRGMEAD MPDEINIDEL LELESEEERS RKIQGLLKSC GKPVEDFIQE LLAKLQGLHR QPGLRQPSPS HDGSLSPLQD RARTAHP|
|Grade & Purity||> 95% pure|
|Molecular Weight||18 kDa (167 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 2mM EDTA, 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization. Recombinant His tagged PPP1R14A was expressed in E. coli and purified by using conventional chromatography techniques.|
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