Prealbumin protein (30R-1456)
Purified recombinant Human Prealbumin protein
|Synonyms||Amyloidosis I protein, TBPA protein, HsT2651 protein, Transthyretin protein, Prealbumin amyloidosis type I protein, Amyloid polyneuropathy protein, Senile systemic amyloidosis protein, ATTR protein, Dysprealbuminemic euthyroidal hyperthyroxinemia protein, TTR protein, PALB protein, Dystransthyretinemic hyperthyroxinemia protein, TTR protein.|
Coomassie Blue stained SDS-PAGE of Prealbumin protein (30R-1456)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||21-147 amino acids: MGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGELHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKE|
|Grade & Purity||> 95% pure|
|Molecular Weight||13.8 kDa (128aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in PBS, pH 7.4, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Prealbumin, also known as Transthyretin, is a tetrameric human plasma protein that is synthesized mainly in the liver. This protein transports the thyroid hormone thyroxine (T4) and retinol (Vitamin A). It is the best indicator of protein-energy malnutrition because it has a circulating half life of 2 days and responds rapidly to changes in nutritional status. Also point-mutations of its gene are known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC). Recombinant human Prealbumin was expressed in E. coli and purified by using conventional chromatography.|
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