Protein A (30-AP76)

Immunoglobulin-binding bacterial Protein A solution

Species S.aureus
Protein Type Native
Applications User optimized

Specifications

Source Staphylococcus aureus
Grade & Purity > 95% pure
Form & Buffer Supplied as a lyophilized powder.

Storage & Safety

Storage Aliquot and store at -20 deg C. Avoid repeated Freeze/Thaw cycles

General Information

Biological Significance Protein A is a 40-60 kDa MSCRAMM surface protein originally found in the cell wall of the bacteria Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins. It binds proteins from many of mammalian species, most notably IgGs. It binds with the Fc region of immunoglobulins through interaction with the heavy chain. The result of this type of interaction is that, in serum, the bacteria will bind IgG molecules in the wrong orientation (in relation to normal antibody function) on their surface which disrupts opsonization and phagocytosis.

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Availability: In stock

Price: £797.24
Size: 10 mg
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