PSMA7 protein (His tag) (80R-1098)
Purified recombinant Human PSMA7 protein
|Synonyms||PSMA7 protein, PSMA7, PSMA-7, Proteasome subunit alpha 4 protein, Proteasome subunit alpha type 7 protein, C6 protein, Proteasome alpha 7 subunit protein, Proteasome subunit RC6 1 protein, Proteasome alpha 7 subunit Proteasome (prosome macropain) subunit alpha type 7 protein, PSMA 7, PSMA 7 protein, XAPC7 protein, PSMA-7 protein, RC6-1 protein, Proteasome alpha 7 subunit protein, PSMA 7 protein, RC6 1 protein, HSPC protein, Proteasome subunit XAPC7., MGC3755 protein|
Coomassie Blue stained SDS-PAGE of PSMA7 protein (His tag) (80R-1098)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-248 amino acids: MGSSHHHHHH SSGLVPRGSH MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE KKKQKKAS|
|Grade & Purity||> 90% pure|
|Molecular Weight||30.0 kDa (268 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Proteasome alpha 7, PSMA7, is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. PSMA7, belonged to the peptidase T1A family, is a 20S core alpha subunit of proteasome. This protein was found to interact specifically with two subdomains of HIF-1alpha and inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions. Recombinant PSMA7 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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