PTS protein (30R-1452)

Purified recombinant Human PTS protein

Synonyms FLJ97081 protein, 6-pyruvoyltetrahydropterin synthase 6 pyruvoyl tetrahydrobiopterin synthase protein, EC 4.2.3.12 protein, PTP synthase protein, 6 pyruvoyl tetrahydropterin synthase protein, , 6 pyruvoyltetrahydropterin synthase protein, PTPS protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of PTS protein (30R-1452)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-145 amino acids: MGSSHHHHHH SSGLVPRGSH MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE
Expression System E.coli
Grade & Purity > 90% pure
Molecular Weight 18.5 kDa (165aa), confirmed by MALDI-TOF.
Form & Buffer Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT and 20% glycerol.
Concentration 1 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance 6-Pyruvoyltetrahydropterin synthase (PTS), also known as PTPS, belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. Recombinant human PTS, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

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Images

  • Coomassie Blue stained SDS-PAGE of PTS protein (30R-1452) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: £176.28
Size: 100 ug
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