PTTG1 protein (His tag) (80R-1183)
Purified recombinant Human PTTG1 protein
|Synonyms||PTTG1 protein protein, PTTG 1, SECURIN protein, Esp1-associated protein protein, PTTG 1 protein, EAP1 protein, PTTG protein, Pituitary tumor-transforming gene 1 protein protein, TUMOR TRANSFORMING 1 protein, PTTG1 protein, Pituitary tumor-transforming 1 protein, PTTG-1, Tumor transforming protein 1 protein, AW555095 protein, Pituitary tumor transforming protein 1 protein, Pituitary tumor transforming 1 protein, PTTG-1 protein, HPTTG protein, MGC126883 protein, EAP 1 protein, Pituitary tumor-transforming 1 protein, PTTG1, TUTR1 protein, MGC138276 protein, PTTG 1 protein, Pds1 protein, TUTR 1 protein, Cut2 protein, Pttg3 protein, C87862 protein, Pituitary tumor-transforming protein 1 ESP1 ASSOCIATED PROTEIN 1 protein, isoform CRA_b protein, , Pituitary tumor-transforming gene 1 protein, hPTTG protein, isoform CRA_a protein|
Coomassie Blue stained SDS-PAGE of PTTG1 protein (His tag) (80R-1183)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-202 amino acids: MGSSHHHHHH SSGLVPRGSH MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ SPSSILSTLD VELPPVCCDI DI|
|Grade & Purity||> 80% pure|
|Molecular Weight||24.1 kDa (222aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 0.1 M NaCl, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||PTTG1, also known as Securin, is primarily involved in the regulation of sister chromatid separation during cell division. It has two identified roles; the first one is to help the transport of separase(cysteine protease) to the nucleus and the second role is to inhibit the catalytic activity of separase. It is ubiquitinated by the Anaphase Promoting Complex (APC), and then degraded by the Proteasome, releasing separase. Recombinant PTTG1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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