RAB5B protein (His tag) (80R-1605)
Purified recombinant Human RAB5B protein
|Synonyms||Ras related protein Rab 5B, RAB5B, Rab 5b protein, Ras-related protein Rab-5B protein, RABB-5, RAB5B member RAS oncogene family protein, RABB-5 protein, RABB 5 protein, RABB 5, Rab5 b protein|
Coomassie Blue stained SDS-PAGE of RAB5B protein (His tag) (80R-1605)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-215 amino acids: MGSSHHHHHH SSGLVPRGSH MGSMTSRSTA RPNGQPQASK ICQFKLVLLG ESAVGKSSLV LRFVKGQFHE YQESTIGAAF LTQSVCLDDT TVKFEIWDTA GQERYHSLAP MYYRGAQAAI VVYDITNQET FARAKTWVKE LQRQASPSIV IALAGNKADL ANKRMVEYEE AQAYADDNSL LFMETSAKTA MNVNDLFLAI AKKLPKSEPQ NLGGAAGRSR GVDLHEQSQQ NKSQCCSN|
|Grade & Purity||> 90% pure|
|Molecular Weight||26.1 kDa (238aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 20% glycerol and 0.2M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Ras-related protein Rab-5B, also known as RAB5B, is a member of the Rab family of small (monomeric) G proteins. RAB5B is involved in endocytosis and recycling of cell surface molecules. It interacts with RIN2 and RIN3, which regulate its function, possibly by acting as GEFs. Knockdown of RAB5B abolished group I metabotropic glutamate receptor (mGluR)-mediated neuroprotection. Recombinant human RAB5B protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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