Rabbit IgG (Fc) (31C-CH1104)
Purified Rabbit IgG (Fc)
|Synonyms||Rabbit Immunoglobulin G (Fc)|
SDS-PAGE analysis of Rabbit IgG (Fc) (31C-CH1104)
Lane M: 3 uL MW Marker. Lane 1: Reduced Rabbit IgG Whole Molecule. Lane 2: Reduced Rabbit IgG F(ab) Fragment. Lane 3: Reduced Rabbit IgG F(c) Fragment. Lane 4: Reduced Rabbit IgM Whole Molecule. Load: 1 ug for F(ab) and F(c); 1.2 ug for IgG and IgM. Predicted/Observed size: IgG at 50 and 25 kDa; F(c) at 25 kDa; F(ab) at 25 kDa; IgM at 70 and 23 kDa. Observed F(c) Fragment migrates slightly higher.
|Method of Purification||Rabbit IgG (Fc) was purified by affinity chromatography.|
|Form & Buffer||0.02M K3PO4, pH 7.2, with 0.15M NaCl, and 0.01% NaN3.|
Storage & Safety
|Storage||Store at 4 deg C. Dilute only prior to immediate use.|
|Biohazard Information||This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.|
|Biological Significance||Immunoglobulin G (IgG) are antibody molecules. Each IgG is composed of four peptide chains - two heavy chains and two light chains. Each IgG has two antigen binding sites. Other Immunoglobulins may be described in terms of polymers with the IgG structure considered the monomer. The Fc regions of IgGs bear a highly conserved N-glycosylation site. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and alpha-2,6-linked sialic acid residues.|
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