RGS5 protein (His tag) (80R-1931)
Purified recombinant RGS5 protein
|Synonyms||MSTP129 protein, RGS-5, Regulator of G-protein signaling 5 protein, RGS 5 protein, MSTP106 protein, MST129 protein, RGS5, RGS-5 protein, RGS 5, MST092 protein, MSTP032 protein, MSTP092 protein, MST106 protein|
|Assay Information||RGS5 protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.|
Coomassie Blue stained SDS-PAGE of RGS5 protein (His tag) (80R-1931)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-181 amino acids: MGSSHHHHHH SSGLVPRGSH MGSHMCKGLA ALPHSCLERA KEIKIKLGIL LQKPDSVGDL VIPYNEKPEK PAKTQKTSLD EALQWRDSLD KLLQNNYGLA SFKSFLKSEF SEENLEFWIA CEDYKKIKSP AKMAEKAKQI YEEFIQTEAP KEVNIDHFTK DITMKNLVEP SLSSFDMAQK RIHALMEKDS LPRFVRSEFY QELIK|
|Grade & Purity||> 90% pure|
|Molecular Weight||23.5 kDa|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, with 20% glycerol, 0.1M NaCl and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C or -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||RGS5, also known as regulator of G-protein signaling 5, binds directly to activated G alpha subunits and acts as a GTPase-activating protein (GAPs) to attenuate and/or modulate hormone and neurotransmitter receptor-initiated signaling by both G alpha-GTP and G beta gamma. Vascular endothelial cells express the RGS protein RGS5, where it correlates with capillary morphogenesis, thus rendering it a candidate gene involved in capillary growth, angiogenesis, and also potentially the pathophysiology of stroke. Recombinant human RGS5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
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