SAR1A protein (His tag) (80R-1168)
Purified recombinant Human SAR1A protein
|Synonyms||SARA 1, SAR1 protein, Masra 2 protein, cerevisiae) protein, SAR1A, SAR1 gene homolog A protein, SAR1 homolog A (S protein, SARA 1 protein, SAR1a gene homolog (S cerevisiae) 1 protein, COPII-associated small GTPase protein, SARA1 protein, SARA-1 protein, Sara protein, SAR 1 protein, SAR1A protein, SARA 1., Masra2 protein, SAR1a gene homolog 1 COPII associated small GTPase protein, SARA-1, SAR1a gene homolog 1 (S cerevisiae) protein, GTP binding protein SAR1a protein|
Coomassie Blue stained SDS-PAGE of SAR1A protein (His tag) (80R-1168)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-198 amino acids: MGSSHHHHHH SSGLVPRGSH MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID|
|Grade & Purity||> 90% pure|
|Molecular Weight||24.5 kDa (218aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||SAR1a gene homolog 1, also known as SAR1A, belongs to the small GTPase superfamily. Sar1 is an essential component of COPII vesicle coats involved in export of cargo from the ER. The GTPase activity of Sar1 functions as a molecular switch to control protein-protein and protein-lipid interactions that direct vesicle budding from the ER. GDP-bound Sar1 interacts with the membrane-bound exchange factor Sec12 and exchanges its bound GDP for GTP. Recombinant human SAR1A, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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