Scl-70 protein (30-AS70)

Purified Native Bovine Scl-70 protein

Synonyms Scleroderma protein, Scl70 protein, Scl-70, Scl- 70, Scl--70, Scl--70 protein, Scl- 70 protein
Species Bovine
Protein Type Native
Applications User optimized

Specifications

Source Calf Thymus
Grade & Purity > 90% pure
Molecular Weight 68-75 kDa
Form & Buffer Supplied in 20 mM Hepes-NaOH, pH 7.5; 0.32 M NaCl; 0.1 mM PMSF; 0.2 mM DTT; 0.1% (v/v) Micr-O-protect; 20% (v/v) glycerol

Storage & Safety

Storage Store at -20 deg C
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Scl-70 is an antigen present on topoisomerase I, which is an ubiquitous intranuclear enzyme that mediates the twisting and untwisting of the DNA helix during gene transcription. It is a basic nuclear protein with a molecular weight of 70,000 daltons. Antibodies directed against Scl-70 usually give a nucleolar ANA pattern and are present exclusively in 70% of patients with severe, diffuse forms of progressive systemic sclerosis, also known as scleroderma.

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Availability: In stock

Price: £396.62
Size: 200 ug
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