SET7/9 protein (30R-1046)
Purified recombinant Human SET7/9 protein
|Synonyms||EC 126.96.36.199 protein, SET-7 + SET-9, SET domain-containing protein 7 protein, SET7 + SET9, SET-7 + SET-9 protein, Histone H4-K4 methyltransferase protein, SET 7/9 protein, SET7 protein, SET7/9, SET7/9 protein, SET D7 protein, KIAA1717 protein, Lysine N-methyltransferase 7 protein, SET 7/9, H4 lysine-4 specific protein, SET9 protein, H3 K4 HMTase protein, Histone H3 K4 methyltransferase protein, SET 9 protein, , SET-7/9 protein, Histone H3 lysine 4 specific methyltransferase protein, SET-7/9, SET 7/9 protein, Histone H3-K4 methyltransferase SETD7 protein, SET domain-containing protein 8 protein, SET domain containing protein 7 protein, H3-K4-HMTase SETD7 protein, SET7 + SET9 protein, KMT7 protein, SETD7 protein, Histone-lysine N-methyltransferase SETD7 protein, Histone lysine N methyltransferase H3 lysine 4 specific SET7 protein, Lysine methyltransferase protein, SET domain-containing protein 7 FLJ21193 protein, Histone-lysine N-methyltransferase protein, SET7/9 Histone methyltransferase protein, SET 7 protein|
Coomassie Blue stained SDS-PAGE of SET7/9 protein (30R-1046)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK|
|Grade & Purity||> 95% pure|
|Molecular Weight||40.7 kDa (366 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 50mM Tris-HCl buffer, pH7.5, containing 0.2M NaCl, 5mM DTT, and 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||Set 7/9 is a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.|
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