SH2D1A antibody (70R-10049)
Affinity purified rabbit polyclonal SH2D1A antibody
|Synonyms||Polyclonal SH2D1A antibody, Anti-SH2D1A antibody, IMD5 antibody, MTCP1 antibody, FLJ18687 antibody, XLPD antibody, SH2 domain protein 1A antibody, SHD1A 2 antibody, SHD1A-2, EBVS antibody, XLP antibody, DSHP antibody, SHD1A 2, SHD1A-2 antibody, LYP antibody, SAP antibody, FLJ92177 antibody, SH2D1A|
|Immunogen||SH2D1A antibody was raised in rabbit using the C terminal of SH2D1A as the immunogen|
|Assay Information||SH2D1A Blocking Peptide, catalog no. 33R-10098, is also available for use as a blocking control in assays to test for specificity of this SH2D1A antibody|
Western Blot analysis using SH2D1A antibody (70R-10049)
SH2D1A antibody (70R-10049) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.|
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