SH2D1A protein (His tag) (80R-1544)
Purified recombinant Human SH2D1A protein
|Synonyms||SHD1A-2 protein, DSHP protein, MTCP1 protein, SHD1A 2 protein, SAP protein, EBVS protein, SH2D1A, XLP protein, SH2 domain-containing protein 1A protein, SHD1A-2, XLPD, SHD1A 2, LYP protein, IMD5 protein|
Coomassie Blue stained SDS-PAGE of SH2D1A protein (His tag) (80R-1544)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-128 amino acids: MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP|
|Grade & Purity||> 95% pure|
|Molecular Weight||16.3 kDa(148aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 1mM DTT, 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||SH2D1A is an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. This protein is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD) also known as Duncan disease. XLPD is characterized by a rare congenital immunodeficiency following Epstein-Barr virus (EBV) infection. Recombinant human SH2D1A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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