Sheep anti Human IgA (20C-CR6043SP)

Sheep anti Human IgA antibody

Synonyms Polyclonal Human IgA antibody, Anti-Human IgA antibody, Immunoglobulin A antibody
Specificity Human
Cross Reactivity To be determined by end-user
Applications Immunodiffusion, ODD, WB
Immunogen Human IgA antibody was raised in sheep using human secretory piece purified from human colostrum as the immunogen.

Specifications

Host Sheep
Form & Buffer Supplied as a liquid in GBS.
Concentration Batch dependent - please inquire should you have specific requirements

Usage & Assay Information

Usage Recommendations ODD: 10 uL antiserum vs 10 uL Milk, WB: 100 uL antiserum vs 10 uL Milk, Immunodiffusion: 16 uL antiserum/cm^2 in gel vs 5 uL Milk, dilutions: Neat - 1:15.

Storage & Safety

Storage Store at 4 deg C.

General Information

Biological Significance The secretory piece is a component of immunoglobulin A which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, is free to diffuse throughout the lumen.

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Availability: In stock

Price: £141.82
Size: 1 ml
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