SIRT6 protein (His tag) (80R-1073)
Purified recombinant Human SIRT6 protein
|Synonyms||SIRT-6, Sirtuin 6 Mono ADP ribosyltransferase sirtuin 6 protein, SIRT-6 protein, SIRT 6 protein, cerevisiae) protein, SIR2L6 protein, SIR2-like protein 6 protein, Sirtuin 6 protein, Sirtuin type 6 protein, SIR2 like protein 6 protein, SIRT 6 protein, SIRT 6, Sir2 related protein type 6 protein, SIRT6, Sirtuin (silent mating type information regulation 2 homolog) 6 (S protein, Sirtuin6., Mono-ADP-ribosyltransferase sirtuin-6 protein|
Coomassie Blue stained SDS-PAGE of SIRT6 protein (His tag) (80R-1073)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-355 amino acids: MGSSHHHHHH SSGLVPRGSH MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA DLRIHGYVDE VMTRLMEHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS|
|Grade & Purity||> 95% pure|
|Molecular Weight||41 kDa (375 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||The SIRT6 is included in class IV of the sirtuin family, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, in yeast sirtuins are known to regulate epigenetic gene silencing. Also SIRT6, a chromatin-associated protein, appears to be involved in DNA repair. Recombinant SIRT6, fused to His-tag at N-terminus, was expressed in E. coli and purified by conventional chromatography techniques.|
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