SQSTM1 protein (His tag) (80R-1297)
Purified recombinant Human SQSTM1 protein
|Synonyms||Sequestosome 1 EBI 3 associated protein of 60 kDa protein, p62B protein, PDB3 protein, STAP protein, ZIP protein, SQSTM-1 protein, p60 protein, Paget disease of bone 3 protein, Protein kinase C-zeta-interacting protein protein, Osi protein, PDB 3 protein, PKC-zeta-interacting protein protein, ORCA.M530 protein, Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa protein, Oxidative stress induced like protein, SQSTM1, A170 protein, ZIP3 protein, EBI3 associated protein of 60 kDa protein, , SQSTM 1, MGC127197 protein, Phosphotyrosine independent ligand for the Lck SH2 domain p62 protein, EBIAP protein, OSIL protein, SQSTM 1 protein, SQSTM 1 protein, SQSTM-1, Ubiquitin binding protein p62 protein, STONE14 protein, p62 protein, ZIP 3 protein, OSF-6 protein|
Coomassie Blue stained SDS-PAGE of SQSTM1 protein (His tag) (80R-1297)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-356 amino acids: MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPLLEHH HHHH|
|Grade & Purity||> 90% pure|
|Molecular Weight||39.7 kDa (364aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in muscle cells. This protein also may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 protein commonly cause Paget?s disease since the UBA is necessary for aggregate sequestration and cell survival. Recombinant SQSTM1 protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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